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The presentation was led by Dr. Mohamed Shamji, Scientific Advisor of ASIT Biotech and Associate Professor at Imperial College London, and took place at MRC & Asthma UK Centre at St Thomas Hospital in London. The Centre was formed in October 2005 as a partnership between the MRC, Asthma UK charity, Imperial College and King’s College London, as well as the NHS Trusts of the two universities. Dr. Shamjis presentation covered a novel approach to treat patients with summer hay fever (seasonal allergic rhinitis) which affect 40% of the global population. More importantly, the lecture specifically highlighted the joint effort between ASIT biotech and Imperial College London to develop novel therapeutic strategies to tackle a serious medical unmet need in the treatment of seasonal allergic rhinitis. His presentation discussed the characterisation of natural pollen peptides using ASIT+ technology platform as well as data illustrating that a short course of Lolium Perenne peptide injections (gp-ASIT+) is safe and effective in grass pollen-induced seasonal allergic rhinitis. It summarized the results of the phase II clinical studies previously disclosed by ASIT biotech. gp-ASIT+ is the Companys most advanced drug candidate. Its clinical efficacy is being investigated in a phase III clinical trial in Europe. The results of this study should be available during the first quarter of 2017.
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“This means medical teams could intervene earlier with alternative treatments, increasing the chances of success and perhaps staving off the need for a liver transplant.” PBC In patients with PBC, the body thinks that the bile ducts within the liver are foreign objects and tries to destroy the lining to these ducts. These bile ducts are designed to allow the flow of bile from the liver, so damage of these ducts leads to poor drainage of bile acids. The bile acids then leak from the bile ducts, damaging surrounding liver cells, which Full Article then causes inflammation and scarring in the liver. PBC is relatively rare affecting up to 1 in 3-4,000 people and of those 9 out of 10 are women. While there is a genetic element to PBC, it is thought to be within the auto-immune family of conditions and experts do not yet know what causes PBC or what can cure it. In the early stages of the disease, PBC often doesn’t cause any symptoms and many people are only diagnosed during tests carried out for another reason. Testing Developed at the NanoString facility within the Faculty of Medical Sciences at Newcastle University, the test raises questions about PBC as lead author, Dr Lucy Walker, explains: “As we have identified a separate gene expression for those with high-risk PBC, it raises the possibility that PBC may actually be two separate conditions with very similar symptoms. This is something we will be examining further in future, larger studies.” This study only examined samples from a small group of patients (13) and a further study into a larger group to validate the results will begin shortly. The work was funded by the Medical Research Council. Dave Jones, Professor of Liver Immunology and co-author on the paper said: “Currently patients with high-risk PBC may be offered immunotherapies, however, these have mixed results and it may be that often the aggressive nature of the condition in high-risk patients means that even as the treatment starts the condition has created too much damage in the liver.
For the original version including any supplementary images or video, visit https://www.eurekalert.org/pub_releases/2016-12/nu-nti120216.php